See Remove Symantec software for Mac using RemoveSymantecMacFiles. Remove legacy Symantec AntiVirus (SAV) for Mac installations before installing Symantec Endpoint Protection.

Case-sensitive APFS volumes are not supported.

As of version 12.1.2, SEP supports case-sensitivity in HFS volumes.

PowerPC processors are not supported as of version 12.1.x.

Neither Apple or Symantec support macOS 10.13.x or older.

Apple M2 Support is currently under investigation, planned support in SEP 14.3 RU6 and later.

Apple M1 (M1 Pro/M1 Max/M1 Ultra) is only supported by SEP 14.3 RU2 and later.

The 14.3 RU4 Full installer download ships with the 14.3 RU3 Mac client. The 14.3 RU5 Mac client will download to the SEPM when Liveupdate is run on the SEPM server.

The 14.3 RU5 Full installer download ships with the 14.3 RU3 Mac client.

The SES Mac client is only supported on macOS 10.15.x and 11.x with the SES Mac agent build 14.3 RU1 and newer.

The Symantec Endpoint Security (SES) client for Mac is cloud-based and managed by the Integrated Cyber Defense Manager (ICDM) web page.

The SEP client for Mac is managed by a Symantec Endpoint Protection Manager (SEPM) on a Windows server.

Note: Different product versions have specific system requirements. SEP 14.x Client for macOS/OS X Compatibility Chart

Macbook pro os x version compatibility